The Effect of Indian-Made Mepacrine Hydrochloride on Plasmodium Knowlesi *Prepared by Bengal Chemical and Pharmaceutical Works Ltd., Calcutta.
نویسندگان
چکیده
The satisfactory results obtained in the treatment of bird malaria (P. relictum) with mepacrine hydrochloride (Das Gupta and Siddons, 1943) encouraged us to try it in P. knowlesi infection in the monkey, Silenus rhesus. It is well known that, in this monkey^ this parasite produces the most intense infection which, if unchecked, usually terminates fatally. Therefore, infected monkeys are very suitable for testing the anti-malarial properties of a drug. Mepacrine is the British Pharmacopceial name for atebrin which has been shown to be effective against P. knowlesi. Methods
منابع مشابه
Synergistic Effect of Chemical Enhancer And Iontophoresis For Transdermal Delivery Of Nebivolol Hydrochloride
The aim of the present study was to develop and investigate the feasibility of delivering Nebivolol as a transdermal patch by iontophoresis. The passive and electrically assisted transdermal delivery of Nebivolol hydrochloride by iontophoresis will improve the therapeutic efficacy and overcome the difficulties raised in oral drug delivery. Because of its extensive hepatic metabolism and low dos...
متن کاملClinical Pharmacology of the Antimalarial Chloroquine in Children and Their Mothers
Plasmodium falciparum, Plasmodium vivax, Plasmodium ovale, Plasmodium malariae, and Plasmodium knowlesi are the parasites that infect humans. Plasmodium falciparum and Plasmodium vivax cause most of the malarial infections worldwide. Plasmodium vivax, Plasmodium ovale, Plasmodium malariae, and Plasmodium knowlesi are susceptible to chloroquine. Chloroquine was the world's most widely used antim...
متن کاملThe Organization of the Calcutta Blood Bank: Donor and Collection Service
The extension of the war made it imperative to start a blood bank on modern lines for the processing of serum or plasma in India. The Government of India took a lead in the matter and early in January 1942, the Calcutta Blood Bank was established at the All-India Institute of Hygiene and Public Health in collaboration with the Bengal Branch of the Indian Red Cross Society. This was the first bl...
متن کاملA Case of Self-treatment Induced Recurrent Fixed Drug Eruptions Associated with the Use of Different Fixed Dose Combinations of Fluoroquinolone-Nitroimidazole
A young male patient used fixed dose combinations of different fluoroquinolones and nitroimidazoles several times in the last few years for self-treating repeated episodes of diarrhea and loose motion. Each time, he experienced fixed drug eruptions that increased in number and severity on subsequent occasions. Suspecting association between the drug and the rashes, the patient each time discont...
متن کاملComplement Fixation in Human Malaria with an Antigen Prepared from the Monkey Parasite Plasmodium Knowlesi
In the studies of complement fixation described in this paper, the antigens were prepared from (a) normal monkey red cells, (b) parasitized red cells of monkeys dying with Plasmodium knowlesi infection, (c) the spleens of monkeys dying with Plasmodium knowlesi infection; the sera came from (a) normal human beings, (b) patients with syphilis, (c) patients with paresis who were receiving malaria ...
متن کامل